The Germany international has not been featuring very much at all in the early part of the new season with the 22 year old taking part in just one substitute appearance in the EPL at the weekend out of a possible four matches.
The departure of Gareth Bale has had a big effect on the pecking order at White Hart Lane with the likes of Paulinho, Christian Eriksen and Etienne Capoue joining as part of the transfer fee received for Bale with midfielders Dembele, Sandro and Sigurdsson also preferred over Holtby.
Inter Milan and Roma are both interested in the midfielder and sources believe that a bid of around 8.5 million euros could be enough to lure him away.
Holtby may be forced into making a move elsewhere with hopes of retaining a regular spot in the German squad with the World Cup looming next year.